PREMATURE OVARIAN FAILURE
\pɹɪmət͡ʃˈʊ͡əɹ ə͡ʊvˈe͡əɹi͡ən fˈe͡ɪli͡ə], \pɹɪmətʃˈʊəɹ əʊvˈeəɹiən fˈeɪliə], \p_ɹ_ɪ_m_ə_tʃ_ˈʊə_ɹ əʊ_v_ˈeə_ɹ_iə_n f_ˈeɪ_l_iə]\
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Premature failure of ovulation associated with hypergonadotropinism and hypoestrogenism in women under the age of 40. The etiology appears to be multifactorial and many cases are idiopathic. When follicles are present but the ovaries are unable to respond to gonadotropins, resistant ovary syndrome results and this may be associated with autoimmune disease. Even when there is a loss of ovarian follicles, it is not always complete. Permanent and irreversible loss of follicles is termed premature menopause (MENOPAUSE, PREMATURE).
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