PREFERENTIAL
\pɹˌɛfəɹˈɛnʃə͡l], \pɹˌɛfəɹˈɛnʃəl], \p_ɹ_ˌɛ_f_ə_ɹ_ˈɛ_n_ʃ_əl]\
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By William Dodge Lewis, Edgar Arthur Singer
By Nuttall, P.Austin.
By Stormonth, James, Phelp, P. H.
Word of the day
ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.