PRACTICE PATTERN VARIATIONS
\pɹˈaktɪs pˈatən vˌe͡əɹɪˈe͡ɪʃənz], \pɹˈaktɪs pˈatən vˌeəɹɪˈeɪʃənz], \p_ɹ_ˈa_k_t_ɪ_s p_ˈa_t_ə_n v_ˌeə_ɹ_ɪ__ˈeɪ_ʃ_ə_n_z]\
Word of the day
ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.