POLYMERIC IG RECEPTOR
\pˌɒlɪmˈɛɹɪk ˈɪɡ ɹɪsˈɛptə], \pˌɒlɪmˈɛɹɪk ˈɪɡ ɹɪsˈɛptə], \p_ˌɒ_l_ɪ_m_ˈɛ_ɹ_ɪ_k ˈɪ_ɡ ɹ_ɪ_s_ˈɛ_p_t_ə]\
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Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
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