POLARITY OF DEVELOPMENT
\pə͡ʊlˈaɹɪti ɒv dɪvˈɛləpmənt], \pəʊlˈaɹɪti ɒv dɪvˈɛləpmənt], \p_əʊ_l_ˈa_ɹ_ɪ_t_i_ ɒ_v d_ɪ_v_ˈɛ_l_ə_p_m_ə_n_t]\
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The morphological expression of genetic control of body shape. Clusters of homeotic genes control the morphology of animal body plans and body parts. Different body patterns may evolve through changes in gene number, regulation, or function. Recent evidence suggests that homeotic gene clusters were duplicated early in vertebrate evolution, but that arthropod and tetrapod diversity has largely involved regulatory changes in expression. (From Nature 1995 Aug 10;376 (6540):479-85)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.