\plˈɪkɐmˌɪsɪn], \plˈɪkɐmˌɪsɪn], \p_l_ˈɪ_k_ɐ_m_ˌɪ_s_ɪ_n]\
Definitions of PLICAMYCIN
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A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
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bcr v abl Oncogene
- Retrovirus-associated DNA sequences (abl) originally isolated from Abelson murine leukemia virus (Ab-MuLV). proto-oncogene abl (codes for a protein that member tyrosine kinase family. human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It activated by translocation to bcr 22 in chronic myelogenous leukemia.