PITUITARY DIABETES INSIPIDUS
\pɪtjˈuːɪtəɹi da͡ɪ͡əbˈiːtiːz ɪnsˈɪpɪdəs], \pɪtjˈuːɪtəɹi daɪəbˈiːtiːz ɪnsˈɪpɪdəs], \p_ɪ_t_j_ˈuː_ɪ_t_ə_ɹ_i d_aɪə_b_ˈiː_t_iː_z ɪ_n_s_ˈɪ_p_ɪ_d_ə_s]\
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Deficiency of vasopressin secretion from the posterior pituitary gland. Clinical manifestations include extreme thirst, polydipsia, and reduced serum osmolality. Potential etiologies include CRANIOCEREBRAL TRAUMA; post-neurosurgical states; HYPOTHALAMIC NEOPLASMS; PITUITARY NEOPLASMS; CENTRAL NERVOUS SYSTEM INFECTIONS; PITUITARY APOPLEXY; CEREBROVASCULAR DISORDERS; granulomatous diseases (including SARCOIDOSIS); and other conditions. The disorder may also be inherited as an autosomal or recessive trait. (From Joynt, Clinical Neurology, 1992, Ch 36, pp55-8)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.