PITUITARY APOPLEXY
\pɪtjˈuːɪtəɹi ˈapəplˌɛksi], \pɪtjˈuːɪtəɹi ˈapəplˌɛksi], \p_ɪ_t_j_ˈuː_ɪ_t_ə_ɹ_i_ ˈa_p_ə_p_l_ˌɛ_k_s_i]\
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Sudden hemorrhage or ischemic necrosis involving the pituitary gland which may be associated with acute visual loss, severe headache, meningeal signs, cranial nerve palsies, panhypopituitarism, and rarely COMA. The most common cause is hemorrhage (INTRACRANIAL HEMORRHAGES) related to a pituitary ADENOMA (see also PITUITARY NEOPLASMS). Ischemia; MENINGITIS; INTRACRANIAL HYPERTENSION; and other disorders may be associated with this condition.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.