PHOTOFRIN II
\fˈə͡ʊtə͡ʊfɹˌɪn ɹˌə͡ʊmən tˈuː], \fˈəʊtəʊfɹˌɪn ɹˌəʊmən tˈuː], \f_ˈəʊ_t_əʊ_f_ɹ_ˌɪ_n ɹ_ˌəʊ_m_ə_n_ t_ˈuː]\
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The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.