PHENACETIN O DEALKYLASE
\fˈɛnɐsˌɛtɪn ˈə͡ʊ dˈiːlkɪlˌe͡ɪs], \fˈɛnɐsˌɛtɪn ˈəʊ dˈiːlkɪlˌeɪs], \f_ˈɛ_n_ɐ_s_ˌɛ_t_ɪ_n ˈəʊ d_ˈiː_l_k_ɪ_l_ˌeɪ_s]\
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A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-.
By DataStellar Co., Ltd
Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.
Nearby Words
- phema
- phemeride
- phemerol
- phemethryn
- phenacetin
- Phenacetin O Dealkylase
- phenacetin, phenacetinum (br.)
- phenacetine
- phenacetinum
- phenacetinurethan
- phenaceturic acid