PERSISTENT FETAL CIRCULATION
\pəsˈɪstənt fˈiːtə͡l sˌɜːkjʊlˈe͡ɪʃən], \pəsˈɪstənt fˈiːtəl sˌɜːkjʊlˈeɪʃən], \p_ə_s_ˈɪ_s_t_ə_n_t f_ˈiː_t_əl s_ˌɜː_k_j_ʊ_l_ˈeɪ_ʃ_ə_n]\
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A syndrome of persistent pulmonary hypertension in the newborn infant, without demonstrable cardiac disease. It is characterized by cyanosis and acidosis, severe pulmonary vasoconstriction, hypertrophy of pulmonary arterial muscle, and elevated pulmonary vascular resistance, with resultant right-to-left shunting of blood through a patent ductus arteriosus and at times a patent foramen ovale.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.