P70S6K
\pˈiː sˈɛvəntˌi z sˈɪks kˈe͡ɪ], \pˈiː sˈɛvəntˌi z sˈɪks kˈeɪ], \p_ˈiː s_ˈɛ_v_ə_n_t_ˌi z s_ˈɪ_k_s k_ˈeɪ]\
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A protein serine/threonine kinase which is involved in cell transformation by polyoma virus and is connected to the expression of IGF2. The immunosuppressant rapamycin inhibits the activation of the kinase, leading to reduced translation of certain mRNAs and a decrease in protein synthesis. EC 2.7.10.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.