P42(MAPK)
\pˈiː fˈɔːtitˈuː mˈapk], \pˈiː fˈɔːtitˈuː mˈapk], \p_ˈiː f_ˈɔː_t_i_t_ˈuː__ m_ˈa_p_k]\
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Extracellular signal-regulated kinase 2. A proline-directed serine/threonine kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to translocation into the nucleus and phosphorylation of certain transcription factors. p40 MAPK and p41 MAPK are isoforms. EC 2.7.10.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.