P21(C KI RAS)
\pˈiː twˈɛntiwˈɒn sˈiː kˈa͡ɪ ɹˈɑːz], \pˈiː twˈɛntiwˈɒn sˈiː kˈaɪ ɹˈɑːz], \p_ˈiː t_w_ˈɛ_n_t_i_w_ˈɒ_n__ s_ˈiː k_ˈaɪ ɹ_ˈɑː_z]\
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Cellular protein encoded by the H-ras, K-ras and N-ras genes. The protein has GTPase activity and is involved in signal transduction as a monomeric GTP-Binding protein. Elevated levels of p21 c-ras have been associated with neoplasia. EC 3.6.1.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.