Definitions of p190 (MET)

  1. A cell surface protein- tyrosine kinase receptor for HEPATOCYTE GROWTH FACTOR. It consists of an extracellular alpha chain which is disulfide- linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and critical sites for the regulation of kinase activity. Mutations of the gene for PROTO- ONCOGENE PROTEIN C- MET are associated with papillary renal carcinoma and other neoplasia. EC 2. 7. 11.-.