P105 RB PROTEIN
\pˈiː wˈɒnhˈʌndɹədən fˈa͡ɪv ˌɑːbˈiː pɹˈə͡ʊtiːn], \pˈiː wˈɒnhˈʌndɹədən fˈaɪv ˌɑːbˈiː pɹˈəʊtiːn], \p_ˈiː w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈaɪ_v ˌɑː_b_ˈiː p_ɹ_ˈəʊ_t_iː_n]\
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Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.