P1 ENDONUCLEASE
\pˈiː wˈɒn ˈɛndə͡ʊnjˌuːklɪˌe͡ɪs], \pˈiː wˈɒn ˈɛndəʊnjˌuːklɪˌeɪs], \p_ˈiː w_ˈɒ_n ˈɛ_n_d_əʊ_n_j_ˌuː_k_l_ɪ__ˌeɪ_s]\
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An enzyme that catalyzes endonucleolytic cleavage to 5-phosphomononucleotides and 5-phosphooligonucleotide end-products. It has a preference for single-stranded substrates but is active with either ribo- or deoxyribonucleic acids. (From Enzyme Nomenclature, 1992) EC 3.1.30.1.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.