P(ARF) PROTEIN
\pˈiː ˌe͡ɪˌɑːɹˈɛf pɹˈə͡ʊtiːn], \pˈiː ˌeɪˌɑːɹˈɛf pɹˈəʊtiːn], \p_ˈiː__ ˌeɪ_ˌɑː_ɹ_ˈɛ_f__ p_ɹ_ˈəʊ_t_iː_n]\
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A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of mdm2 protein (which regulates p53 by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is PROTEIN P16. Both p16 gene products have tumor suppressor functions.
By DataStellar Co., Ltd
