Definitions of P Glycoproteins

  1.   A subfamily of transmembrane proteins from the superfamily of ATP BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P GLYCOPROTEIN When overexpressed they function as ATP dependent efflux pumps able to extrude lipophilic drugs especially ANTINEOPLASTIC AGENTS from cells causing multidrug resistance DRUG RESISTANCE MULTIPLE Although P Glycoproteins share functional similarities to MULTIDRUG RESISTANCE ASSOCIATED PROTEINS they are two distinct subclasses of ATP BINDING CASSETTE TRANSPORTERS and have little sequence homology