ORIGIN OF REPLICATION
\ˈɒɹɪd͡ʒˌɪn ɒv ɹˌɛplɪkˈe͡ɪʃən], \ˈɒɹɪdʒˌɪn ɒv ɹˌɛplɪkˈeɪʃən], \ˈɒ_ɹ_ɪ_dʒ_ˌɪ_n ɒ_v ɹ_ˌɛ_p_l_ɪ_k_ˈeɪ_ʃ_ə_n]\
Definitions of ORIGIN OF REPLICATION
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A unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. It contains the sites where the first separation of the complementary strands occurs, a primer RNA is synthesized, and the switch from primer RNA to DNA synthesis takes place. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
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- Complication diabetes from severe insulin deficiency coupled with an absolute or relative increase in concentration. metabolic acidosis is caused by breakdown of adipose stores and resulting increased levels free fatty acids. Glucagon accelerates the oxidation acids producing excess ketone bodies (ketosis).