OPTIC PAPILLA EDEMA
\ˈɒptɪk papˈɪləɹ ˈɛdɪmə], \ˈɒptɪk papˈɪləɹ ˈɛdɪmə], \ˈɒ_p_t_ɪ_k p_a_p_ˈɪ_l_ə_ɹ ˈɛ_d_ɪ_m_ə]\
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Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.