ONCOGENE
\ˈɒnkə͡ʊd͡ʒˌiːn], \ˈɒnkəʊdʒˌiːn], \ˈɒ_n_k_əʊ_dʒ_ˌiː_n]\
Definitions of ONCOGENE
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By Princeton University
By DataStellar Co., Ltd
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Genes which can potentially induce neoplastic transformation. They include genes for growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. When these genes are constitutively expressed after structural and/or regulatory changes, uncontrolled cell proliferation may result. Viral oncogenes have prefix "v-" before the gene symbol; cellular oncogenes (PROTO-ONCOGENES) have the prefix "c-" before the gene symbol.
By DataStellar Co., Ltd
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.