NUCLEAR AND CYTOPLASMIC RECEPTORS
\njˈuːkli͡əɹ and sˌa͡ɪtəplˈazmɪk ɹɪsˈɛptəz], \njˈuːkliəɹ and sˌaɪtəplˈazmɪk ɹɪsˈɛptəz], \n_j_ˈuː_k_l_iə_ɹ a_n_d s_ˌaɪ_t_ə_p_l_ˈa_z_m_ɪ_k ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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Proteins in the cytoplasm or nucleus that specifically bind signaling molecules and trigger changes which influence the behavior of cells. The major groups are the steroid hormone receptors (RECEPTORS, STEROID), which usually are found in the cytoplasm, and the thyroid hormone receptors (RECEPTORS, THYROID HORMONE), which usually are found in the nucleus. Receptors, unlike enzymes, generally do not catalyze chemical changes in their ligands.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
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