NORMOKALEMIC PERIODIC PARALYSES
\nˌɔːməke͡ɪlˈiːmɪk pˌi͡əɹɪˈɒdɪk pˈaɹəlˌa͡ɪzɪz], \nˌɔːməkeɪlˈiːmɪk pˌiəɹɪˈɒdɪk pˈaɹəlˌaɪzɪz], \n_ˌɔː_m_ə_k_eɪ_l_ˈiː_m_ɪ_k p_ˌiə_ɹ_ɪ__ˈɒ_d_ɪ_k p_ˈa_ɹ_ə_l_ˌaɪ_z_ɪ_z]\
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A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481)
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Nearby Words
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