NONCHROMAFFIN PARAGANGLIOMA
\nˌɒnkɹˈə͡ʊmɐfˌɪn pˌaɹəɡˌaŋɡlɪˈə͡ʊmə], \nˌɒnkɹˈəʊmɐfˌɪn pˌaɹəɡˌaŋɡlɪˈəʊmə], \n_ˌɒ_n_k_ɹ_ˈəʊ_m_ɐ_f_ˌɪ_n p_ˌa_ɹ_ə_ɡ_ˌa_ŋ_ɡ_l_ɪ__ˈəʊ_m_ə]\
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A relatively rare, usually benign neoplasm originating in the chemoreceptor tissue of the carotid body, glomus jugulare, and aortic bodies. It consists histologically of rounded or ovoid hyperchromatic cells that tend to be grouped in an alveolus-like pattern within a scant to moderate amount of fibrous stroma and a few large thin-walled vascular channels. They are uncommon before the age of 20, with a female predominance in some series. (Stedman, 25th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p570-1)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.