NOMIFENSINE MALEATE
\nˈɒma͡ɪfnsˌa͡ɪn mˈe͡ɪle͡ɪt], \nˈɒmaɪfnsˌaɪn mˈeɪleɪt], \n_ˈɒ_m_aɪ_f_n_s_ˌaɪ_n m_ˈeɪ_l_eɪ_t]\
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An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.