NEURAL TUBE DEVELOPMENTAL DEFECTS
\njˈuːɹə͡l tjˈuːb dɪvˈɛləpmˈɛntə͡l dˈiːfɛkts], \njˈuːɹəl tjˈuːb dɪvˈɛləpmˈɛntəl dˈiːfɛkts], \n_j_ˈuː_ɹ_əl t_j_ˈuː_b d_ɪ_v_ˈɛ_l_ə_p_m_ˈɛ_n_t_əl d_ˈiː_f_ɛ_k_t_s]\
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Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.