NEURAL TUBE DEFECT
\njˈuːɹə͡l tjˈuːb dˈiːfɛkt], \njˈuːɹəl tjˈuːb dˈiːfɛkt], \n_j_ˈuː_ɹ_əl t_j_ˈuː_b d_ˈiː_f_ɛ_k_t]\
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Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
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