N NITROSODIMETHYLAMINE DEMETHYLASE
\ˈɛn nˌa͡ɪtɹə͡ʊsˌɒda͡ɪmθˈɪlɐmˌiːn dˈɛmiːθˌɪle͡ɪs], \ˈɛn nˌaɪtɹəʊsˌɒdaɪmθˈɪlɐmˌiːn dˈɛmiːθˌɪleɪs], \ˈɛ_n n_ˌaɪ_t_ɹ_əʊ_s_ˌɒ_d_aɪ_m_θ_ˈɪ_l_ɐ_m_ˌiː_n d_ˈɛ_m_iː_θ_ˌɪ_l_eɪ_s]\
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A polymorphic enzyme that activates carcinogenic N-nitrosamines, benzene, urethane, and other low molecular weight compounds. It is inducible by ethanol and metabilizes alcohol. Experimentally, it is used to study the effects of ethanol usage and withdrawal via enzyme markers such as N-nitrosodimethylamine demethylase. (Pharmacogenetics 1995;5 Spec No:S141-4) EC 1.5.99.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.