Definitions of N Methyl D Aspartate Receptors

  1. A class of ionotropic glutamate receptors characterized by affinity for N- methyl- D- aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage- dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions ( as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.