N METHYL D ASPARTATE RECEPTORS
\ˈɛn mˈiːθa͡ɪl dˈiː ɐspˈɑːte͡ɪt ɹɪsˈɛptəz], \ˈɛn mˈiːθaɪl dˈiː ɐspˈɑːteɪt ɹɪsˈɛptəz], \ˈɛ_n m_ˈiː_θ_aɪ_l d_ˈiː_ ɐ_s_p_ˈɑː_t_eɪ_t ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
By DataStellar Co., Ltd
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