N ACETYL BETA D HEXOSAMINIDASE
\ˈɛn ˈasɪtˌa͡ɪl bˈiːtə dˈiː hˈɛksəsˌamɪnˌɪde͡ɪs], \ˈɛn ˈasɪtˌaɪl bˈiːtə dˈiː hˈɛksəsˌamɪnˌɪdeɪs], \ˈɛ_n ˈa_s_ɪ_t_ˌaɪ_l b_ˈiː_t_ə d_ˈiː h_ˈɛ_k_s_ə_s_ˌa_m_ɪ_n_ˌɪ_d_eɪ_s]\
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An enzyme hydrolyzing terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on glucosides, galactosides, and several oligosaccharides. Hexosaminidase A cleaves GM2, GA2, globosides, and hexosamine oligosaccharides. Deficiency of this isoenzyme causes TAY-SACHS DISEASE. Hexosaminidase B cleaves all the above substrates except GM2. A deficiency of both A and B causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease. EC 3.2.1.52.
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hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.