MYOPATHIC MYASTHENIC SYNDROME OF LAMBERT EATON
\mˌa͡ɪəpˈaθɪk mˌa͡ɪɐsθˈɛnɪk sˈɪndɹə͡ʊm ɒv lˈambət ˈiːtən], \mˌaɪəpˈaθɪk mˌaɪɐsθˈɛnɪk sˈɪndɹəʊm ɒv lˈambət ˈiːtən], \m_ˌaɪ_ə_p_ˈa_θ_ɪ_k m_ˌaɪ__ɐ_s_θ_ˈɛ_n_ɪ_k s_ˈɪ_n_d_ɹ_əʊ_m ɒ_v l_ˈa_m_b_ə_t ˈiː_t_ə_n]\
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An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.
Nearby Words
- myopathic atrophy
- myopathic condition
- myopathic conditions
- myopathic muscular atrophy
- myopathic myasthenic syndrome of eaton lambert
- Myopathic Myasthenic Syndrome of Lambert Eaton
- myopathic scoliosis
- myopathic spasm
- myopathies
- myopathies, structural, congenital
- myopathy