MULTISYSTEMIC ATROPHIES
\mˌʌltɪsɪstˈɛmɪk ˈatɹəfɪz], \mˌʌltɪsɪstˈɛmɪk ˈatɹəfɪz], \m_ˌʌ_l_t_ɪ_s_ɪ_s_t_ˈɛ_m_ɪ_k ˈa_t_ɹ_ə_f_ɪ_z]\
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A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6 (1):187-204; Med Clin North Am 1999 Mar;83 (2):381-92)
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