MULTIPLE OSTEOCHONDROMA
\mˈʌltɪpə͡l ˌɒstɪˌɒkəndɹˈə͡ʊmə], \mˈʌltɪpəl ˌɒstɪˌɒkəndɹˈəʊmə], \m_ˈʌ_l_t_ɪ_p_əl ˌɒ_s_t_ɪ__ˌɒ_k_ə_n_d_ɹ_ˈəʊ_m_ə]\
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Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
By DataStellar Co., Ltd
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