MUCHA HABERMANN DISEASE
\mˈʌt͡ʃə hˈabəmˌan dɪzˈiːz], \mˈʌtʃə hˈabəmˌan dɪzˈiːz], \m_ˈʌ_tʃ_ə h_ˈa_b_ə_m_ˌa_n d_ɪ_z_ˈiː_z]\
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A subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis. An important variant of the chronic form is LYMPHOMATOID PAPULOSIS.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.