MOTOR NEURON DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
\mˈə͡ʊtə njˈuːɹɒn dɪzˈiːz], \mˈəʊtə njˈuːɹɒn dɪzˈiːz], \m_ˈəʊ_t_ə n_j_ˈuː_ɹ_ɒ_n d_ɪ_z_ˈiː_z]\
Definitions of MOTOR NEURON DISEASE, AMYOTROPHIC LATERAL SCLEROSIS
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A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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Word of the day
hydromorphic
- [Greek] Structurally adapted to an aquatic environment, as organs of water plants.
Nearby Words
- motor nerve fiber
- motor neuritides
- motor neuritis
- motor neuron
- motor neuron disease
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis
- motor neuron diseases
- motor neurons
- motor neurons, gamma efferent
- motor nucleus
- motor oculi