\mɔːɹˈɪŋɡəɹ ˈaptəɹə], \mɔːɹˈɪŋɡəɹ ˈaptəɹə], \m_ɔː_ɹ_ˈɪ_ŋ_ɡ_ə_ɹ ˈa_p_t_ə_ɹ_ə]\
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1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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ATP Binding Cassette, Sub Family B Proteins

  • A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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