MONONITROGEN MONOXIDE
\mˈɒnə͡ʊnˌa͡ɪtɹəd͡ʒən mʌnˈɒksa͡ɪd], \mˈɒnəʊnˌaɪtɹədʒən mʌnˈɒksaɪd], \m_ˈɒ_n_əʊ_n_ˌaɪ_t_ɹ_ə_dʒ_ə_n m_ʌ_n_ˈɒ_k_s_aɪ_d]\
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A free radical gas produced endogenously by a variety of mammalian cells. It is synthesized from arginine by a complex reaction, catalyzed by NITRIC OXIDE SYNTHASE. Nitric oxide is endothelium-derived relaxing factor. It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP.
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Word of the day
tinctura quininae ammoniata
- A preparation made by dissolving quinin sulphate in alcohol [Br. Ph.].