MONOMERIC G PROTEINS
\mˌɒnə͡ʊmˈɛɹɪk d͡ʒˈiː pɹˈə͡ʊtiːnz], \mˌɒnəʊmˈɛɹɪk dʒˈiː pɹˈəʊtiːnz], \m_ˌɒ_n_əʊ_m_ˈɛ_ɹ_ɪ_k dʒ_ˈiː p_ɹ_ˈəʊ_t_iː_n_z]\
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A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety of intracellular processes. The GTP bound form of the protein is active and limited by its inherent GTPase activity, which is controlled by an array of GTPase activators, GDP dissociation inhibitors, and guanine nucleotide exchange factors. EC 3.6.1.-.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.