MOLECULAR DIAGNOSTIC TECHNIQUE
\məlˈɛkjʊlə dˌa͡ɪəɡnˈɒstɪk tɛknˈiːk], \məlˈɛkjʊlə dˌaɪəɡnˈɒstɪk tɛknˈiːk], \m_ə_l_ˈɛ_k_j_ʊ_l_ə d_ˌaɪ_ə_ɡ_n_ˈɒ_s_t_ɪ_k t_ɛ_k_n_ˈiː_k]\
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MOLECULAR BIOLOGY techniques used in the diagnosis of disease. Included are such techniques as IN SITU HYBRIDIZATION of chromosomes for CYTOGENTIC ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS of gene expression patterns in disease states; identification of pathogenic organisms by analysis of species specific DNA sequences; and detection of mutations with PCR (POLYMERASE CHAIN REACTION).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.