\mˈə͡ʊt pɹˈə͡ʊtiːn], \mˈəʊt pɹˈəʊtiːn], \m_ˈəʊ_t p_ɹ_ˈəʊ_t_iː_n]\
Definitions of MOAT PROTEIN
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A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
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- Complication diabetes from severe insulin deficiency coupled with an absolute or relative increase in concentration. metabolic acidosis is caused by breakdown of adipose stores and resulting increased levels free fatty acids. Glucagon accelerates the oxidation acids producing excess ketone bodies (ketosis).