MITOTIC SPINDLE APPARATUS
\ma͡ɪtˈɒtɪk spˈɪndə͡l ˌapəɹˈe͡ɪtəs], \maɪtˈɒtɪk spˈɪndəl ˌapəɹˈeɪtəs], \m_aɪ_t_ˈɒ_t_ɪ_k s_p_ˈɪ_n_d_əl ˌa_p_ə_ɹ_ˈeɪ_t_ə_s]\
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An organelle consisting of three components: (1) the astral microtubules, which form around each centrosome and extend to the periphery; (2) the polar microtubules which extend from one spindle pole to the equator; and (3) the kinetochore microtubules, which connect the centromeres of the various chromosomes to either centrosome.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.