MILLER FISHER SYNDROME
\mˈɪlə fˈɪʃə sˈɪndɹə͡ʊm], \mˈɪlə fˈɪʃə sˈɪndɹəʊm], \m_ˈɪ_l_ə f_ˈɪ_ʃ_ə s_ˈɪ_n_d_ɹ_əʊ_m]\
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A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37 (9):1493-8)
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