MIL RAF PROTEINS
\ˌɛmˌa͡ɪˈɛl ˌɑːɹˌe͡ɪˈɛf pɹˈə͡ʊtiːnz], \ˌɛmˌaɪˈɛl ˌɑːɹˌeɪˈɛf pɹˈəʊtiːnz], \ˌɛ_m_ˌaɪ_ˈɛ_l ˌɑː_ɹ_ˌeɪ_ˈɛ_f p_ɹ_ˈəʊ_t_iː_n_z]\
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A class of serine-threonine kinases involved in cellular SIGNAL TRANSDUCTION. Included in this class are the proto-oncogene proteins raf and mil (mil is the avian homologue of raf1). Raf is a component of a signal transduction pathway leading to increased gene expression through the c-Jun DNA binding site, AP1.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.