MIGRAINE HEADACHES
\mˈa͡ɪɡɹe͡ɪn hˈɛde͡ɪks], \mˈaɪɡɹeɪn hˈɛdeɪks], \m_ˈaɪ_ɡ_ɹ_eɪ_n h_ˈɛ_d_eɪ_k_s]\
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A subtype of vascular headaches characterized by periodic unilateral pulsatile headaches which begin in childhood, adolescence, or early adult life and recur with diminishing frequency during advancing years. The two major subtypes are CLASSIC MIGRAINE (i.e., migraine with aura) and COMMON MIGRAINE (i.e., migraine without aura). Migrainous episodes may be associated with alterations in cerebral blood flow. (From Adams et al., Principles of Neurology, 6th ed, p172)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.