METABOLIC ACTIVATION
\mˌɛtəbˈɒlɪk ˌaktɪvˈe͡ɪʃən], \mˌɛtəbˈɒlɪk ˌaktɪvˈeɪʃən], \m_ˌɛ_t_ə_b_ˈɒ_l_ɪ_k ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n]\
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The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alteration may be either non-synthetic (OXIDATION-REDUCTION; HYDROLYSIS) or synthetic (glucuronide formation, sulfate conjugation, ACETYLATION; METHYLATION). This also includes metabolic detoxication and clearance.
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