METABOLIC ACTIVATIONS
\mˌɛtəbˈɒlɪk ˌaktɪvˈe͡ɪʃənz], \mˌɛtəbˈɒlɪk ˌaktɪvˈeɪʃənz], \m_ˌɛ_t_ə_b_ˈɒ_l_ɪ_k ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n_z]\
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The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alteration may be either non-synthetic (OXIDATION-REDUCTION; HYDROLYSIS) or synthetic (glucuronide formation, sulfate conjugation, ACETYLATION; METHYLATION). This also includes metabolic detoxication and clearance.
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Word of the day
Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.