METABOLIC ACTIVATION
\mˌɛtəbˈɒlɪk ˌaktɪvˈe͡ɪʃən], \mˌɛtəbˈɒlɪk ˌaktɪvˈeɪʃən], \m_ˌɛ_t_ə_b_ˈɒ_l_ɪ_k ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n]\
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The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alteration may be either non-synthetic (OXIDATION-REDUCTION; HYDROLYSIS) or synthetic (glucuronide formation, sulfate conjugation, ACETYLATION; METHYLATION). This also includes metabolic detoxication and clearance.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.