MEDICAL TOPOGRAPHY
\mˈɛdɪkə͡l təpˈɒɡɹəfi], \mˈɛdɪkəl təpˈɒɡɹəfi], \m_ˈɛ_d_ɪ_k_əl t_ə_p_ˈɒ_ɡ_ɹ_ə_f_i]\
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The systematic surveying, mapping, charting, and description of specific geographical sites, with reference to the physical features that were presumed to influence health and disease. Often associated with Hippocrates, the process became a significant part of public health investigation and epidemiological methodology, particularly between the 17th and 19th centuries. Medical topography should be differentiated from EPIDEMIOLOGY in that the former emphasizes geography whereas the latter emphasizes disease outbreaks. (Dr. James H. Cassedy, NLM History of Medicine Division)
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.