MECHANICAL VENTILATOR WEANING
\mɪkˈanɪkə͡l vˈɛntɪlˌe͡ɪtə wˈiːnɪŋ], \mɪkˈanɪkəl vˈɛntɪlˌeɪtə wˈiːnɪŋ], \m_ɪ_k_ˈa_n_ɪ_k_əl v_ˈɛ_n_t_ɪ_l_ˌeɪ_t_ə w_ˈiː_n_ɪ_ŋ]\
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Techniques for effecting the transition of the respiratory-failure patient from mechanical ventilation to spontaneous ventilation, while meeting the criteria that tidal volume be above a given threshold (greater than 5 ml/kg), respiratory frequency be below a given count (less than 30 breaths/min), and oxygen partial pressure be above a given threshold (PaO2 greater than 50mm Hg). Weaning studies focus on finding methods to monitor and predict the outcome of mechanical ventilator weaning as well as finding ventilatory support techniques which will facilitate successful weaning. Present methods include intermittent mandatory ventilation, intermittent positive pressure ventilation, and mandatory minute volume ventilation.
By DataStellar Co., Ltd
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Procollagen Proline Dioxygenase
- mixed-function oxygenase that catalyzes hydroxylation prolyl-glycyl-containing-peptide, usually in protocollagen, hydroxyprolylglycyl-peptide. The enzyme utilizes molecular oxygen with a concomitant oxidative decarboxylation of 2-oxoglutarate to succinate. EC 1.14.11.2.